Inform eCommerce uses SMTP to send confirmations and internal notifications when an order is placed. You can configure SMTP settings in the Inform Company Master on the SMTP Server Information tab. You can get settings from your email provider.
If you use a Microsoft Exchange server for email, you will need to set up a domain user that is MailBox enabled. Confirmations and notifications can go out under this user name. If you want them to go out under a different account, give the domain user permission to send as that other account.